Patricia A. M. Williams

Doctor en Química
Profesor Titular UNLP
Investigador Principal de CICPBA


Formación de Recursos Humanos

Director de:

Co-director de:


Año 2016
  • J. J. Martínez Medina, L.G. Naso, A. L. Pérez, A. Rizzi, E.G. Ferrer, P.A.M. Williams. Antioxidant and anticancer effects and bioavailability studies of the flavonoid baicalin and its oxidovanadium(IV)complex. Journal of Inorganic Biochemistry, 2016, 166, 150-161. DOI: 10.1016/j.jinorgbio.2016.11.005
  • L.G. Naso, V.R. Martínez, L. Lezama, C. Salado, M. Valcarcel, E.G. Ferrer, P.A.M. Williams. Antioxidant, anticancer activities and mechanistic studies of the flavone glycoside diosmin and its oxidovanadium(IV) complex. Interactions with bovine serum albumin. Bioorganic & Medicinal Chemistry, 2016, 24, 4108-4119. DOI: 10.1016/j.bmc.2016.06.053
  • G. Escudero, N. Martini, K. Jori, N. Jori, N. R. Maresca, C. H. Laino, L.G. Naso, P.A.M. Williams; E.G. Ferrer. Biological activities of Zn(II)-S-methyl-cysteinecomplex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects. Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31, 1625-1631. DOI: 10.3109/14756366.2016.1160900
  • L. G. Naso, L. Lezama, M. Valcarcel, C. Salado, P. Villacé, D. Kortazar, E. G. Ferrer, P. A. M. Williams. Bovine serum albumin binding, antioxidant andanticancer properties of an oxidovanadium(IV) complex with luteolin. Journal of Inorganic Biochemistry, 2016, 167, 80-93. DOI: 10.1016/j.jinorgbio.2016.01.021
  • M. S. Islas, A. Luengo, C.A. Franca, M. Griera Merino, L. Calleros, M. Rodriguez Puyol, L. Lezama, E.G. Ferrer, P.A.M. Williams. Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)-irbesartan complex: structure-antihypertensive activity relationships in Cu(II)-sartan complexes. Journal of Biological Inorganic Chemistry, 2016, 21, 851-863. DOI: 10.1007/s00775-016-1384-5
  • C. Guildori, N. Mosconi, B. Toplikar, M. Vega, P.A.M. Williams, L. Svetaz, M. Raimondi, M. Rizzotto. Heteroleptic complexes of antifungal drugs with the silver ion. Journal of Physical Organic Chemistry, 2016, 29, 656-664. DOI:
  • G. E. Escudero, C. H. Laino, G. A. Echeverría, O. E. Piro, N. Martini, A. Rodríguez, J. J. Martínez Medina, L. L. López Tévez, E. G. Ferrer, P. A. M. Williams. Improving the antidepressant action and the bioavailability of sertraline by co-crystallization with coumarin 3-carboxylate. Structural determination. Chemico-biological Interactions, 2016, 249, 46-55. DOI: 10.1016/j.cbi.2016.03.010
  • L.G. Naso, I. Badiola, J. Márquez Clavijo, M. Valcarcel; C. Salado; E. G. Ferrer, P. A. M. Williams. Inhibition of the metastatic progression of breast and colorectal cancer in vitro and in vivo in murine model by theoxidovanadium (IV) complex with luteolin. Bioorganic & Medicinal Chemistry, 2016, 24, 6004-6011. DOI: 10.1016/j.bmc.2016.09.058
  • N. M. Urquiza, L. G. Naso, J. J. Martínez Medina, M. A. Moyano, L. Lezama, E. G. Ferrer, P. A. M. Williams. Pharmacological activities of propylthiouracil compound structurally modifiedby coordination with copper(II). Journal of Coordination Chemistry, 2016, 69, 1293-1312. DOI: 10.1080/00958972.2016.1167885
Año 2015
  • N. Urquiza, M. S. Islas, S. T. Ariza, N. Jori, J. J. Martínez Medina, M. J. Lavecchia, L. L. López Tévez, L. Lezama, T. Rojo, P.A.M. Williams, E. G. Ferrer. Anti-thyroid and antifungal activities, BSA interaction and acid phosphatase inhibition of methimazole copper(II) complexes. Chemico-Biological Interactions, 2015, n° 229, 64-72. DOI: 10.1016/j.cbi.2014.12.036
  • J. J. Martínez Medina, C.A. Torres, W. Alegre, C.A. Franca, L.L. López Tévez, E. G. Ferrer, N.B. Okulik, P.A.M. Williams. DFT calculations, in vitro antifungal activity, genotoxic effects and acute toxicity of the [Zn(phen)2(cnge)(H2O)](NO3)2·H2O complex. Journal of molecular structure, 2015, 1100, 366-375. DOI: 10.1016/j.molstruc.2015.07.061
  • M. S. Islas, L. G. Naso, L. Lezama, M. Valcarcel, C. Salado, M. Rouraferrer, E. G. Ferrer, P.A.M. Williams. Insights into the mechanisms underlying the antitumor activity of an oxidovanadium(IV) compound with the antioxidant naringenin. Albumin binding studies. Journal of inorganic biochemistry, 2015, 149, 12-24. DOI: 10.1016/j.jinorgbio.2015.04.011
  • A. Colombo, C. Dragonetti, D. Roberto, A. Valore, C. Ferrante, I. Fortunati, A. L. Picone, F. Todescato, J. A. Gareth Williams. Two-photon absorption properties and 1O2 generation ability of Ir complexes: unexpected large cross section of [Ir(CO)2Cl(4-(paradi- n-butylaminostyryl)pyridine). Dalton Transactions, 2015, 44, 15712-15720 DOI: 10.1039/C5DT00552C
Año 2014
  • I. León, V. Porro, A.L. Di Virgilio, L. Naso, P.A.M. Williams, M. Bollati Fogolin, S.B. Etcheverry. Antiproliferative and apoptosis-inducing activity of an oxidovanadium(IV) complex with the flavonoid silibinin against osteosarcoma cells. Journal of Biological Inorganic Chemistry, 2014, 19, 59-74. DOI: 10.1007/s00775-013-1061-x
  • M. S. Islas, J. J. Martínez Medina, L. L. López Tévez, T. Rojo, L. Lezama, M. Griera Merino, L. Calleros, M. A. Cortés, M. Rodriguez Puyol, G. A. Echeverría, O. Piro, E.G. Ferrer, P.A.M. Williams. Antitumoral, Antihypertensive, Antimicrobial and Antioxidant Effects of an Octanuclear Copper(II)-Telmisartan Complex with an Hydrophobic Nanometer Hole. Inorganic Chemistry, 2014, 53, n° 11, 5724-5737. DOI: 10.1021/ic500483p
  • J. J. Martínez Medina, L. L. López Tévez, N. B. Okulik, M. S. Islas, E.G. Ferrer, P.A.M. Williams. Copper(II) complexes with cyanoguanidine and o-phenanthroline: Theoretical studies, in vitro antimicrobial activity and alkaline phosphatase inhibitory effect. Journal of Molecular Structure, 2014, 1058, 298-307. DOI: 10.1016/j.molstruc.2013.11.014
  • P.A.M. Williams. Metal complexes of the antihypertensive drugs that inhibit the renin-angiotensin system. Current Trends in Medicinal Chemistry, 2014, 7, 97-104. ISSN 0973-0532 | Acceso al resumen
  • L. Naso, M. Valcarcel Cuesta, M. Roura-Ferrer, D. Kortazar, C. Salado, L. Lezama, T. Rojo, A. C. González Baro, P. A. M. Williams, E.G. Ferrer. Promising antioxidant and anticancer (human breast cancer) oxidovanadium(IV) complex of chlorogenic acid. Synthesis, characterization and spectroscopic examination on the transport mechanism with bovine serum albumin. Journal of Inorganic Biochemistry, 2014, 135, 86-9.DOI: 10.1016/j.jinorgbio.2014.02.013
  • L. Naso, M. Valcarcel, P. Villacé, M. Roura-Ferrer, C. Salado, E.G. Ferrer, P.A.M. Williams. Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids on human breast cancer cells. New Journal of Chemistry, 2014, 38, 2414-2421. DOI: 10.1039/c3nj01649h