Ignacio E. León

Doctor en Ciencias Biológicas
Ayudante Diplomado UNLP
Investigador Adjunto de CONICET

Director: Susana B. Etcheverry
Co-director: Daniel A. Barrio (CIT-CONICET)

Proyectos de investigación

Formación de Recursos Humanos

Director de:

  • Nadia B. Capdet (Tesinista)
  • Lucía Santa María de la Parra (Tesinista)

Co-director de:


Año 2016
  • J. F. Cadavid-Vargas, I. E. León, S. B. Etcheverry, E. Santi, M. H. Torre, A. L. Di Virgilio. Copper (II) complexes with saccharinate and glutamine as antitumor agents: Cytoand genotoxicity in human osteosarcoma cells. Anti-Cancer Agents in Medicinal Chemistry, 2016, vol. 16. DOI: 10.2174/1871520616666160513130204
  • I. E. León, P. Díez, S. B. Etcheverry, M. Fuentes. Deciphering the effect of an oxovanadium(IV) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line. Metallomics, 2016. DOI: 10.1039/C6MT00045B
  • I. E. León, J.F. Cadavid Vargas, A. Resasco, F. Maschi, M. Ayala, C. Carbone, S. B. Etcheverry. In vitro and in vivo antitumor effects of the VO-Chrysin complex on a new three dimensional osteosarcoma spheroids modeland a xenograft tumor in mice. Journal of Biological Inorganic Chemistry, 2016, 21, 8, 1009-1020. DOI: 10.1007/s00775-016-1397-0
  • I.E. León, J.F. Cadavid Vargas, A.L. Di Virgilio, S.B. Etcheverry. Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity. Current Medicinal Chemistry, 2016, 24. DOI: 10.2174/0929867323666160824162546
Año 2015
  • I. E. León, S. B. Etcheverry, E. J. Baran. Cytotoxicity Action of an Oxidovanadium(IV)- DPPZ Complex on MG 63 Osteosarcoma Cell Line. Bio technology, An Indian Journal, 2015, 11, n° 12, 465-468. ISSN 0974-7435 Texto completo
  • I. E. León, J.F. Cadavid Vargas, I. Tiscornia, V. Porro, S. Castelli, P. Katkar, A. Desideri, M. Bollatifogolin, S.B. Etcheverry. Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model. Journal of biological inorganic chemistry, 2015, 20, Issue 7, 1175-1191. DOI: 10.1007/s00775-015-1298-7
Año 2014
  • I.E. León, V. Porro, A.L. Di Virgilio, L. Naso, P.A.M. Williams, M. Bollati Fogolin, S.B. Etcheverry. Antiproliferative and apoptosis-inducing activity of an oxidovanadium(IV) complex with the flavonoid silibinin against osteosarcoma cells. Journal of Biological Inorganic Chemistry, 2014, 19, 59-74. DOI: 10.1007/s00775-013-1061-x
  • A. M. Alippi, I. E. León, A. C. López. Tetracycline-resistance encoding plasmids from different paenibacillus larvae strains isolated from commercial honeys. International Microbiology, 2014, 49-61. ISSN 1139-6709 DOI: 10.2436/20.1501.01.207
  • I.E. León, V. Porro, S. Astrada, M.G. Egusquiza, C.I. Cabello, M. Bollati Fogolin, S.B. Etcheverry. Polyoxometalates as antitumor agents: Bioactivity of a new polyoxometalate with copper on a human osteosarcoma model. Chemico-Biological Interactions, 2014, 222, 87-96. DOI: 10.1016/j.cbi.2014.10.012
  • I.E. León, N. Butenko, A.L. Di Virgilio, C.I. Muglia, E. J. Baran, I. Cavaco, S. B. Etcheverry. Vanadium and cancer treatment: Antitumoral mechanisms of three oxidovanadium(IV) complexes on a human osteosarcoma cell line. Journal of Inorganic Biochemistry, 2014, 134, 106-117. DOI: 10.1016/j.jinorgbio.2013.10.009