Ignacio E. León

Doctor en Ciencias Biológicas
Profesor Adjunto UNLP
Investigador Independiente de CONICET

 


Proyectos de investigación


Formación de Recursos Humanos

Director de:

  • Lucía M. Balsa (Becaria de CONICET)
  • Tudge Boztepe (Beca en CINDEFI)
  • Martín A. Llanqueleo (Beca Manuel Belgrano)
  • Olivia Espíndola Moreno (Beca Manuel Belgrano)
  • Estefanía Montiel (Beca Estímulo a la vocación científica - C.I.N.)
  • Lucía Santa Maria de la Parra(Beca de CONICET)

Co-director de:

  • Nadia B. Capdet (Beca en IFLP)
  • Camila Merlini (Beca en INBIOFAL)
  • Mariana Rocha (Beca en INBIOFAL)

Publicaciones

Año 2021
  • T. Boztepe, S. Scioli-Montoto, M. E. Ruiz, V. A. Alvarez, G. R. Castro, I. E. León. 8-Hydroxyquinoline platinum(II) loaded nanostructured lipid carriers: synthesis, physicochemical characterization and evaluation of antitumor activity. New Journal of Chemistry, 2021, 45, 821-830. DOI: 10.1039/D0NJ03940C

  • L. M. Balsa, V. Ferraresi-Curotto, M. J. Lavecchia, G. A. Echeverría, O. E. Piro, J. García-Tojal, R. Pis-Diez, A. C. González-Baró, I. E. León.
    Anticancer activity of a new copper(II) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models. Dalton Transactions, 50(28), 9812-9826, 2021. DOI: 10.1039/D1DT00869B

  • P. Levín, L. M. Balsa, C. P. Silva, A. E. Herzog, A. Vega, J. Pavez, I. E. León, L. Lemus.
    Artificial chemical nuclease and cytotoxic activity of a mononuclear copper(I) complex and a related binuclear double‐stranded helicate. European Journal of Inorganic Chemistry, 2021. DOI: 10.1002/ejic.202100673

  • T. Boztepe, G. R. Castro, I. E. León.
    Lipid, Polymeric, Inorganic-based Drug Delivery Applications for Platinum-based Anticancer Drugs. International Journal of Pharmaceutics, 605, 120788, 2021. DOI: 10.1016/j.ijpharm.2021.120788

  • V. A. Ferretti, I. E. León. Long Non-coding RNAs in Cisplatin Resistance in Osteosarcoma. Current Treatment Options in Oncology, 2021, 22, 41. DOI: 10.1007/s11864-021-00839-y

  • A. I. B. Romo, M. P. Carepo, P. Levín, O. R. Nascimento, D. E. Diaz, J. Rodríguez-López, I. E. León, L. F. Bezerra, L. Lemus, I. C. N. Diógenes.
    Synergy of DNA intercalation and catalytic activity of a copper complex towards improved polymerase inhibition and cancer cell cytotoxicity. Dalton Transactions, 50(34), 11931-11940, 2021. DOI: 10.1039/D1DT01358K

  • M. R. Rodríguez, L. M. Balsa, O. E. Piro, G. A. Etcheverría, J. García-Tojal, R. Pis-Diez, I. E. León, B. S. Parajón-Cost, A. C. González-Baró. Synthesis, Crystal Structure, Spectroscopic Characterization, DFT Calculations and Cytotoxicity Assays of a New Cu(II) Complex with an Acylhydrazone Ligand Derived from Thiophene. Inorganics 2021, 9(2), 9. DOI: 10.3390/inorganics9020009

  • D. Fabra, A. I. Matesanz, J. M. Herrero, C. Alvarez, L. M. Balsa, I. E. Leon, A. G. Quiroga. Two Different Thiosemicarbazone Tauto-Conformers Coordinate to Palladium (II). Stability and Biological Studies of the Final Complexes. European Journal of Inorganic Chemistry, 2021, 11, 1041-1049. DOI: 10.1002/ejic.202001066

  • P. Levín, M. C. Ruiz, A. I. B. Romo, O. R. Nascimento, A. L. Di Virgilio, A. G. Oliver, A. P. Ayala, I. C. N. Diógenes, I. E. León, L. Lemus.
    Water-mediated reduction of [Cu(dmp)2(CH3CN)]2+: Implications of the structure of a classical complex on its activity as an anticancer drug. Inorganic Chemistry Frontiers, 2021. DOI: 10.1039/D1QI00233C

Año 2020
  • P. O. Abate, M. Sottile, I. E. León, M. M. Vergara, N. E. Katz.
    A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer. Journal of the Brazilian Chemical Society, 2020, 0, 0, 1-8. DOI: 10.21577/0103-5053.20200085

  • L. M. Balsa, M. C. Ruiz, L. Santa Maria de la Parra, E. J. Baran, I. E. León.
    Anticancer and antimetastatic activity of copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres. Journal of Inorganic Biochemistry, 2020, 204, 110975. DOI: 10.1016/j.jinorgbio.2019.110975

  • J. B. Ferrado, A. A. Perez, M. C. Ruiz, I. E. León, L. G. Santiago.
    Chrysin-loaded bovine serum albumin particles as bioactive nanosupplements. Food & Function, 2020, 7, 11, 6007-6019. DOI: 10.1039/D0FO00299B

  • B. Bueloni, D. Sanna, E. Garribba, G. R. Castro, I. E. León, G. A. Islan.
    Design of nalidixic acid-vanadium complex loaded into chitosan hybrid nanoparticles as smart strategy to inhibit bacterial growth and quorum sensing.
    International Journal of Biological Macromolecules, 2020, 161, 1568-1580. DOI: 10.1016/j.ijbiomac.2020.07.304

  • C. Ventura, I. E. León, A. Asuaje, P. Martín, N. Enrique, M. Núñez, C. Cocca, V. Milesi.
    Differential expression of the long and truncated Hv1 isoforms in breast-cancer cells. Journal of Cellular Physiology, 2020. DOI: 10.1002/jcp.29719

  • L. M. Balsa, P. Quispe, E. J. Baran, M. J. Lavecchia, I. E. León. In silico and in vitro analysis of FAK/MMP signaling axis inhibition by VO-clioquinol in 2D and 3D human osteosarcoma cancer cells. Metallomics, 2020, 12, 1931-1931. DOI: 10.1039/D0MT00176G

  • A. M. Silva-Nolasco, L. Camacho, R. O. Saavedra-Díaz, O. Hernández-Abreu, I. E. León, I. Sánchez-Lombardo. Kinetic Studies of Sodium and Metforminium Decavanadates Decomposition and In Vitro Cytotoxicity and Insulin- Like Activity. Inorganics 2020, 8(12), 67. DOI: 10.3390/inorganics8120067

  • M. Cipriani, S. Rostán, I. E. León, Z-H. Li, J. S. Gancheff, U. Kemmerling, C. Olea Azar, S. B. Etcheverry, R. Docampo, D. Gambino, L. Otero.
    Multi-target heteroleptic palladium bisphosphonate complexes. JBIC Journal of Biological Inorganic Chemistry, 2020, 25, 509–519. DOI: 10.1007/s00775-020-01779-y

Año 2019
  • J. F. Cadavid-Vargas, C. Villa-Pérez, M. C. Ruiz, I. E. León, G. C. Valencia-Uribe, D. B. Soria, S. B. Etcheverry, A. L. Di Virgilio.
    6-Methoxyquinoline complexes as lung carcinoma agents: induction of oxidative damage on A549 monolayer and multicellular spheroid model. Journal of Biological Inorganic Chemistry, 2019, 24, 2, 271-285. DOI: 10.1007/s00775-019-01644-7

  • M. C. Ruiz, J. Kljun, I. Turel, A. L. Di Virgilio, I. E. León.
    Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer. Metallomics, 2019, 11, 666-675. DOI: 10.1039/C8MT00369F

  • M. R. Rodríguez, J. Del Plá, L. M. Balsa, I. E. León, O. E. Piro, G. A. Echeverría, J. García-Tojal, R. Pis-Diez, B. S. Parajón-Costa, A. C. González-Baró.
    Cu(II) and Zn(II) complexes with a poly-functional ligand derived from o-vanillin and thiophene. Crystal structure, physicochemical properties, theoretical studies and cytotoxicity assays against human breast cancer cells. New Journal of Chemistry, 2019, 43, 7120-7129. DOI: 10.1039/C8NJ06274A

  • M. Rocha, M. C. Ruiz, G. A. Echeverría, O. Piro, I. E. Leon, A. L. Di Virgilio, A. Frontera, D. Gil.
    Diethylaminophenyl-based Schiff base Cu(ii) and V(iv) complexes: experimental and theoretical studies and cytotoxicity assays. New Journal of Chemistry, 2019, 43, 18832-18842. DOI: 10.1039/C9NJ04975D

  • M. C. Ruiz, A. Resasco, A. L. Di Virgilio, M. Ayala, I. Cavaco, S. Cabrera, J. Aleman, I. E. León.
    In vitro and in vivo anticancer effects of two quinoline–platinum(II) complexes on human osteosarcoma models. Cancer Chemotherapy and Pharmacology, 2019, 83, 681-692. DOI: 10.1007/s00280-019-03773-x

  • M. L. Cacicedo, M. C. Ruiz, S. Scioli-Montoto, M. E. Ruiz, M. A. Fernández, R. M. Torres-Sanchez, E. J. Baran, G. R. Castro, I. E. León.
    Lipid nanoparticles – Metvan: revealing a novel way to deliver a vanadium compound to bone cancer cells. New Journal of Chemistry, 2019, 43, 17726-17734. DOI: 10.1039/C9NJ01634A

  • I. E. León, M. C. Ruiz, C. A. Franca, B. S. Parajón-Costa, E. J. Baran.
    Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines. Biological Trace Element Research, 2019, 191, 81-87. ISSN(Print) 0163-4984 | ISSN(Online) 1559-0720 | DOI: 10.1007/s12011-018-1597-2

  • P. A. Quispe, M. J. Lavecchia, I. E. León.
    On the discovery of a potential survivin inhibitor combining computational tools and cytotoxicity studies. Heliyon, 2019, 5, e02238. DOI: 10.1016/j.heliyon.2019.e02238

  • M. R. Rodríguez, L. M. Balsa, J. Del Plá, J. García-Tojal, R. Pis-Diez, B. S. Parajón-Costa, I. E. León, A. C. González-Baró.
    Synthesis, characterization, DFT calculations and anticancer activity of a new oxidovanadium(IV) complex with a ligand derived from o-vanillin and thiophene. New Journal of Chemistry, 2019, 43, 11784-11794. DOI: 10.1039/C9NJ02092F

  • Y. Burgos López, J. Del Pla, L. M. Balsa, I. E. León, G. A. Echeverría, O. E. Piro, J. García-Tojal, R. Pis-Diez, A. C. González-Baró, B. S. Parajón-Costa.
    Synthesis, crystal structure and cytotoxicity assays of a copper(II) nitrate complex with a tridentate ONO acylhydrazone ligand. Spectroscopic and theoretical studies of the complex and its ligand. Inorganica Chimica Acta, 2019, 487, 31-40. DOI: 10.1016/j.ica.2018.11.039

Año 2018
  • M. L. Cacicedo, G. A. Islan, I. E. León, V. A. Álvarez, I. Chourpa, E. Allard-Vannier, N. García-Aranda, Z. V. Díaz-Riascos, Y. Fernández, S. Schwartz, I. Abasolo, G. R. Castro. Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment. Colloids and Surfaces B: Biointerfaces, 2018, 170, 596-608. DOI: 10.1016/j.colsurfb.2018.06.056

  • A. I. Matesanz, E. Jimenez-Faraco, M. C. Ruiz, L. M. Balsa, C. Navarro-Ranninger, I. E. León, A. G. Quiroga. Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media. Inorganic Chemistry Frontiers, 2018, 5, 73-83. DOI: 10.1039/C7QI00446J

  • J. Kljun, I. E. León, Š. Peršič, J. Cadavid Vargas, S. B. Etcheverry, W. He, Y. Bai, I. Turel. Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines. Journal of Inorganic Biochemistry, 2018, 186, 187-196. DOI: 10.1016/j.jinorgbio.2018.05.009

Año 2017
  • I. E. León, P. Díez, E. J. Baran, S. B. Etcheverry, M. Fuentes. Decoding the Anticancer Activity of VO-Clioquinol Compound: The Mechanism of Action and Cell Death Pathways in Human Osteosarcoma Cells. Metallomics, 2017, 9, 7, 891-901. DOI: 10.1039/c7mt00068e

  • I. E. León, J. F. Cadavid Vargas, A. L. Di Virgilio, S. B. Etcheverry. Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity. Current Medicinal Chemistry, 2017, 24, 2. ISSN: 0929-8673 | DOI: 10.2174/0929867323666160824162546

Año 2016
  • J. F. Cadavid-Vargas, I. E. León, S. B. Etcheverry, E. Santi, M. H. Torre, A. L. Di Virgilio. Copper (II) complexes with saccharinate and glutamine as antitumor agents: Cytoand genotoxicity in human osteosarcoma cells. Anti-Cancer Agents in Medicinal Chemistry, 2016, vol. 17. DOI: 10.2174/1871520616666160513130204

  • I. E. León, P. Díez, S. B. Etcheverry, M. Fuentes. Deciphering the effect of an oxovanadium(IV) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line. Metallomics, 2016. DOI: 10.1039/C6MT00045B

  • I. E. León, J.F. Cadavid Vargas, A. Resasco, F. Maschi, M. Ayala, C. Carbone, S. B. Etcheverry. In vitro and in vivo antitumor effects of the VO-Chrysin complex on a new three dimensional osteosarcoma spheroids modeland a xenograft tumor in mice. Journal of Biological Inorganic Chemistry, 2016, 21, 8, 1009-1020. DOI: 10.1007/s00775-016-1397-0

  • I.E. León, J.F. Cadavid Vargas, A.L. Di Virgilio, S.B. Etcheverry. Vanadium, Ruthenium and Copper Compounds: A New Class of Nonplatinum Metallodrugs with Anticancer Activity. Current Medicinal Chemistry, 2016, 24. DOI: 10.2174/0929867323666160824162546

Año 2015
  • I. E. León, B. S. Parajón-Costa, C. A. Franca, S. B. Etcheverry, E. J. Baran. A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz: Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line. Biological Trace Element Research, 2015, 164, 198-204. ISSN(Print) 0163-4984 | ISSN(Online) 1559-0720 | DOI: 10.1007/s12011-014-0206-2

  • I. E. León, S. B. Etcheverry, E. J. Baran. Cytotoxicity Action of an Oxidovanadium(IV)- DPPZ Complex on MG 63 Osteosarcoma Cell Line. Bio technology, An Indian Journal, 2015, 11, n° 12, 465-468. ISSN 0974-7435 Texto completo

  • I. E. León, J.F. Cadavid Vargas, I. Tiscornia, V. Porro, S. Castelli, P. Katkar, A. Desideri, M. Bollatifogolin, S.B. Etcheverry. Oxidovanadium(IV) complexes with chrysin and silibinin: anticancer activity and mechanisms of action in a human colon adenocarcinoma model. Journal of biological inorganic chemistry, 2015, 20, Issue 7, 1175-1191. DOI: 10.1007/s00775-015-1298-7

Año 2014
  • I.E. León, V. Porro, A.L. Di Virgilio, L. Naso, P.A.M. Williams, M. Bollati Fogolin, S.B. Etcheverry. Antiproliferative and apoptosis-inducing activity of an oxidovanadium(IV) complex with the flavonoid silibinin against osteosarcoma cells. Journal of Biological Inorganic Chemistry, 2014, 19, 59-74. DOI: 10.1007/s00775-013-1061-x

  • A. M. Alippi, I. E. León, A. C. López. Tetracycline-resistance encoding plasmids from different paenibacillus larvae strains isolated from commercial honeys. International Microbiology, 2014, 49-61. ISSN 1139-6709 DOI: 10.2436/20.1501.01.207

  • I.E. León, V. Porro, S. Astrada, M.G. Egusquiza, C.I. Cabello, M. Bollati Fogolin, S.B. Etcheverry. Polyoxometalates as antitumor agents: Bioactivity of a new polyoxometalate with copper on a human osteosarcoma model. Chemico-Biological Interactions, 2014, 222, 87-96. DOI: 10.1016/j.cbi.2014.10.012

  • I.E. León, N. Butenko, A.L. Di Virgilio, C.I. Muglia, E. J. Baran, I. Cavaco, S. B. Etcheverry. Vanadium and cancer treatment: Antitumoral mechanisms of three oxidovanadium(IV) complexes on a human osteosarcoma cell line. Journal of Inorganic Biochemistry, 2014, 134, 106-117. DOI: 10.1016/j.jinorgbio.2013.10.009